Mark Opler, founder of ProPhase, is currently Chief Scientific Officer of MedAvanta-ProPhase and assistant professor in the Department of Psychiatry at New York University School of Medicine. He focuses on the research of the etiology, phenomenology, and related treatment for severe and persistent mental disorders. He is also a co-author and developer of several clinical assessment tools, including SNAPSI, CGI-DS, and NY-AACENT, as well as a contributor to the latest version of the PANSS manual.

His research has been supported by the NIMH, the Brain and Behavior Foundation (formerly NARSAD), the Stanley Medical Research Institute, and the Qatar National Research Fund. In the meantime, he also has co-authored over 50 peer-reviewed publications and contributed significantly to numerous books on clinical assessment, research methods on mental health.